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High Degree of Heterogeneity in Alzheimer's Disease Progression Patterns

Abstract.

There have been several reports on the varying rates of progression among Alzheimer's Disease (AD) patients; however, there has been no quantitative study of the amount of heterogeneity in AD. Obtaining a reliable quantitative measure of AD progression rates and their variances among the patients for each stage of AD is essential for evaluating results of any clinical study. The Global Deterioration Scale (GDS) and Functional Assessment Staging procedure (FAST) characterize seven stages in the course of AD from normal aging to severe dementia. Each GDS/FAST stage has a published mean duration, but the variance is unknown. We use statistical analysis to reconstruct GDS/FAST stage durations in a cohort of 648 AD patients with an average follow-up time of 4.78 years. Calculations for GDS/FAST stages 4–6 reveal that the standard deviations for stage durations are comparable with their mean values, indicating the presence of large variations in the AD progression among patients. Such amount of heterogeneity in the course of progression of AD is consistent with the existence of several sub-groups of AD patients, which differ by their patterns of decline.


阿爾茨海默病進展模式中的非均質性程度高

抽象。

上的不同費率的級數阿爾茨海默氏病 (AD) 患者 ； 有幾個報告但是，在廣告中一直沒有金額的異質性的定量研究。每個階段的廣告獲得可靠的定量測量的廣告進展率和其患者之間的差異是必要的評估任何臨床研究的結果。全球惡化分攤比額表 (GDS) 和功能評估分期程式 (快速) 特點從正常老化嚴重癡呆症是在 AD 中的七個階段。GDS/快速的每個階段的已發佈平均持續時間，但方差未知。我們使用的統計分析來重建 GDS/快速階段工期與平均 4.78 年的後續行動時間 648 AD 病人的佇列中。GDS/快速階段 4-6 的計算顯示標準差為階段工期並與它們平均的值，指示的患者當中的 AD 進展大變化存在相媲美。這種過程進展的 AD 中的非均質性的金額是衰落的符合存在的幾個組別，AD 病人，由它們的模式不同。

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